Diane-35 Birth Control Pills 21 Tablets / Pack
Diane-35 known as Dianette in some countries is a combination of progestogen-oestrogen which is used for prevention of undesirable pregnancy and androgenisation in the woman. Diane-35 is a drug of chose for women who prefer hormonal birth control and who suffer from acne and androgen-dependent diseases.
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Diane-35 contains two active ingredients - synthetic progestogen called cyproterone acetate and sysnthetic oestrogen - ethinyloestradiol.
How does Diane-35 pill work?
Diane-35 is low-dose monophasic combined oral hormonal contraceptive with antiandrogenic effects (estrogen anti-androgenic drug). Pharmacological properties of Diane-35 are determined by its its two active ingredients - cyproterone acetate and ethinylestradiol. The medication possesses two main effects: contraceptive and anti-androgenic effect.
Antiandrogen effect of Diane-35 pills contrceptive.
Cyproterone acetate possesses the ability to bind to the receptors of the natural male sex hormones - androgens which are produced not only in the male sex glands, but in small amounts in women, mainly in the adrenal glands, ovaries and skin . Cyproterone reduces the effects of androgens produced in the female body, allowing treating diseases caused by excessive formation of androgens or an increased susceptibility to them. Derivatives of the skin such as sebaceous glands and hair follicles are androgen-dependent entities respond to increased levels of androgen production by increasing of sebum production. Sebum is a pathogenic factor in the development of seborrhea and acne (blackheads) and excessive hair growth in women all over the body or its separate parts for male pattern (hirsutism), while loss of hair (androgenic alopecia). Cyproterone blocks the androgen receptors in target organs, thus, reduces the effects of androgens. The therapeutic effect of Diane-35 is manifested in the healing of acne, preventing the formation of new acne forms, reducing excessive sebaceous excretions on the scalp of catches and the skin. In most cases, Diane-35 helps eliminate acne within 3-4 months. Reduction of hirsutism symptoms can be expected only in a few months after starting treatment with DIANE-35.
Contraceptive action of DIANE-35.
Diane-35 birth control drug provides several ways to prevent pregnancy, the most important of which is ovulation inhibition o and change the viscosity of cervical mucus. Along with ant androgenic properties, cyproterone has progestogenic activity. Cyproterone works by inhibiting the secretion of pituitary gonadotropin-releasing hormone and inhibits ovulation, causing a contraceptive effect. At the same time Ethinylestradiol enhances central and peripheral effect of cyproterone on ovulation, retains a high viscosity of cervical mucus, making it difficult penetration of sperm cells into the uterus. Diane-35 guarantees almost 100% protections from undesirable pregnancy. As with all combined oral contraceptives, Diane-35 has a positive effect on the non-contraceptive health. Menstruation becomes easier and shorter, which reduces the risk of iron deficiency anemia, pain in dysmenorrhea become less pronounced or disappear entirely.
When Diane-35 is prescribed?
Diane-35 is used to treat androgen-dependent and hyperandrogenic disorders in women:
- Acne (acne vulgaris), especially in their expressed form, accompanied by seborrhea, inflammatory phenomena to the formation of nodes
- Androgenetic alopecia (hair loss);
- Hirsutism - hair growth in male pattern (light form);
- Oral contraception in women with symptoms of androgenization.
Diane-35 Dosage and Administration
Diane-35 ED should be taken regularly in order to achieve therapeutic efficacy and the needed contraceptive protection. Previously used hormonal oral birth control pills should be discontinued. The dose regimen of Diane-35 is similar to other birth control drugs. The irregular use of Diane-35 may result in intermenstrual bleeding and could decrees the therapeutic and birth control effects.
How to take Diane-35 pills?
One tablet of Diane-35 should to be taken daily. The tablets must be taken in the order directed on the pack at about the same time every day, with some liquid as needed. You should take tablets for 21 days starting with a tablet corresponding to that day of the week. Thereafter, one tablet is taken daily, following the arrows marked on the pack, until all tablets have been taken. Each subsequent pack is started the day after the last tablet of the previous pack was taken.
Do not use DIANE-35 if any of the following conditions apply to you:
Idiosyncrasy (including history of hypersensitivity) to any components of Diane-35;
Severe liver damage and liver tumors
Dubin-Johnson and Rotor syndrome (hereditary benign hyperbilirubinemia);
Diseases accompanied by disorders of hemostasis with a tendency to thrombosis, Thromboembolic processes (transient ischemic attack, angina pectoris, cerebrovascular accident, stroke, myocardial infarction, deep vein thrombosis, pulmonary embolism, diabetes mellitus with vascular complications (diabetic microangiopathy)
Sickle cell anemia
Breast cancer and endometrial cancer, hormone-dependent cancers;
Lipid disorders, pancreatitis (including history), unless it was accompanied by severe Hypertriglyceridemia
Idiopathic jaundice during pregnancy, severe pruritus or herpes Progressive otosclerosis during pregnancy Vaginal/uterine bleeding of unspecified etiology
History of migraine, which was accompanied by focal neurological symptoms
Pregnancy and lactation
Diane-35 should not be used by men
Diane-35 contraceptive can be taken only under strict supervision of a physician in the following cases:
- Diabetes mellitus
- Varicose veins
- Multiple sclerosis
Which are Diane-35 pills side effects?
Diane-35 is generally well tolerated and does not cause side effects and complications in the most cases. However, some women may experience the following side effects: Hormonal system: a sense of tension and tenderness in the breast, breast enlargement, weight change and sex drive, intermenstrual bleeding, vaginal secretions change.
Central nervous system: headache (migraine), depressed mood.
Gastrointestinal system: nausea, vomiting, stomach pain
Cardiovascular system: high blood pressure.
Dermatological reactions: occurrence of pigment spots on the face (chloasma), growing in long-term exposure to the sun.
Other: allergic reactions in very rare cases there may be a poor tolerance of contact lenses.
The probability of these side effects is increased when taking Diane-35 without professional advice.
Which are Diane-35 drug interactions?
If you take Diane-35 you need to know that inductors of microsomal liver enzymes (, barbiturates, primidone, carbamazepine, phenytoin, rifampin, and possibly also with oxcarbazepine, topiramate, increases the clearance of ethinylestradiol and cyproterone, which may lead to vaginal bleedings and loss of contraceptive effect.
Birth control effect of Diane-35 is decreased when the medication is used in combination with certain antibiotics such as ampicillin, tetracycline. Diane 35 may change the blood levels of anti-diabetic drugs.
Expiry date: Long Expiry Date
Quantity: 21 Tablets / Pack
Full Description ;
Diane-35 Birth Control Pills 21 Tablets/Pack
Product Name : Diane-35 21 Tablets/Pack
Active Ingredient: Cyproterone acetate 2mg/ethinyl estradiol 0.035mg
Manufacturer : Bayer
Product Type : Antiandrogen (progestagen) and oral contraceptive (oestrogen)
Diane-35 21's Product Information
Diane 35 tablets contain a combination of ethinyloestradiol, a synthetic oestrogen and cyproterone acetate, an antiandrogen that work together to reverse the effects of too much androgen, like acne and hirsutism, while acting as a contraceptive.
Diane 35 general information
What is Diane 35 used for?
Diane 35 tablets are used to treat women with severe signs of androgenisation (overproduction of androgen), that can produce conditions like hirsutism (unwanted hair) and androgenic alopecia (hair loss) both caused by excess androgen production. These conditions are often accompanied by acne, inflammation and seborrhoea (greasy skin from too much sebum). Diane 35 tablets reduce the symptoms of androgen-dependent conditions where oral antibiotic or local treatment alone has not been successful. Diane 35 tablets can also be used for oral contraception at the same time as they are being used to treat androgen-dependent conditions, however, they should not be used for contraception alone. Diane 35 tablets can be used for the treatment of polycystic ovary syndrome, which is also caused by excess androgen and is usually accompanied by acne and hirsutism.
How does Diane 35 work?
Diane 35 tablets contain a combination of ethinyloestradiol, a synthetic oestrogen, and cyproterone acetate, which is a derivative of progestagen and is also an antiandrogen. These two hormones work together to reverse the effects of too much androgen, while at the same time protecting against pregnancy. Although androgens, one of which is testosterone, are considered primarily male hormones, women also produce androgens, although in much smaller amounts. Androgens have several functions in the female body, including puberty related changes like pubic hair growth, preventing bone loss, libido and for the production of oestrogen. However, some women produce too much androgen and this can cause hirsutism (unwanted hair) and other unwanted symptoms of androgen overproduction like acne and/or seborrhoea (greasy skin from too much sebum) and androgen-dependent alopecia (hair loss). Cyproterone in Diane 35 tablets blocks the production of androgens by the ovaries and binds to the androgen receptors on specific cells in the pilosebaceous unit in the skin (contains sebum-producing sebaceous glands and hair follicles), blocking the androgen-dependent over stimulation of sebum and over production of hair. The ethinyloestradiol component enhances the effect of cyproterone by reducing the amount of androgens in the circulation, relieving symptoms like acne and hirsutism. The combination of a progestagen (cyproterone) and an oestrogen (ethinyloestradiol) in Diane 35 tablets, provides effective contraception, by blocking ovulation, preventing development of the endometrium so that a fertilised egg would not be able to implant and grow, and preventing the thinning of cervical secretions so that sperm cannot get through.
What does Diane 35 contain?
Diane 35 contain 21 tablets with active ingredients consisting of a combination of ethinyloestradiol, a synthetic oestrogen, and cyproterone acetate, which is a progestagen and also an antiandrogen, that work together to reverse the effects of too much androgen, while at the same time protecting against pregnancy. They also contain lactose monohydrate, maize starch, povidone 25, magnesium stearate, sucrose, povidone 700 000, macrogol 6000, calcium carbonate, talc, glycerol 85%, titanium dioxide, ferric oxide pigment (yellow), ferric oxide pigment (red), montanglycol wax, glycerol.
Treating acne with Diane 35
Diane 35 tablets contain a combination of ethinyloestradiol, a synthetic oestrogen, and cyproterone acetate, which is a derivative of progestagen and is also an antiandrogen. These two hormones work together to reverse the effects of too much androgen. Although androgens, are primarily male hormones (like testosterone) women also produce androgens, although in much smaller amounts, which are needed for puberty related changes like pubic hair growth, preventing bone loss, libido and for the production of oestrogen. However, some women produce too much androgen and this can cause over production of sebum (oil produced by sebum glands in the skin) which blocks hair follicles causing acne and/or seborrhoea (greasy skin from too much sebum). Cyproterone in Diane 35 tablets blocks the production of androgens by the ovaries and binds to the androgen receptors on specific cells in the pilosebaceous units in the skin (contain sebum-producing sebaceous glands and hair follicles), blocking the androgen-dependent over stimulation of sebum and over production of hair. The ethinyloestradiol component enhances the effect of cyproterone by reducing the amount of androgens in the circulation, relieving symptoms like acne.
Diane 35 for contraception
Diane 35 tablets contain a combination of ethinyloestradiol, a synthetic oestrogen, and cyproterone acetate, which is a derivative of progestagen and is also an antiandrogen. These two hormones work together to reverse the effects of too much androgen, while at the same time protecting against unwanted pregnancy. The combination of a progestagen (cyproterone) and an oestrogen (ethinyloestradiol) in Diane 35 tablets, provides effective contraception, by blocking ovulation, preventing development of the endometrium so that a fertilised egg would not be able to implant and grow, and preventing the thinning of cervical secretions so that sperm cannot get through.
Diane 35 for transgender hormone therapy
Diane 35 tablets contain a combination of ethinyloestradiol, a synthetic oestrogen, and cyproterone acetate, which is a derivative of progestagen and is also an antiandrogen. The cyproterone component can be used as a substitute for spironolactone as the antiandrogen component of transgender feminising hormone therapy for male to female transsexuals, if small doses of antiandrogen are required.
What are the side effects of Diane 35?
The most frequently reported side effects when taking Diane 35 tablets are: breast tenderness, breast pain, abdominal pain, nausea, oedema, and headache, skin rash and itching, insomnia and depression. Less common side effects include: migraine, fluid retention, changes in body weight, changes in libido.
When should Diane 35 not be used?
You should not use Diane 35 if you:
- are taking another form of oral contraception, as Diane 35 inhibits ovulation and therefore prevents conception
- are allergic to ethinyloestradiol or cyproterone or any of the ingredients in Diane 35 tablets
- have a past or family history of carcinoma of the breast, endometrial carcinoma or liver disease
- have high blood pressure, lipid disorders or migraine
- have had deep venous thrombosis, thromboembolic disorders, heart attack or stroke
- have diabetes with changes to the blood vessels
- are a diabetic taking antidiabetics or insulin, without discussion with your doctor, as the cyproterone in Diane 35 tablets may affect your glucose tolerance
- have abnormal genital bleeding of unknown cause
- are pregnant or planning to become pregnant
- are taking other medications that may interact with Diane 35, such as anticonvulsants like phenytoin and carbamazepin, barbiturates, anti-infectives like rifampicin, rifabutin, nevirapine, the antifungal griseofulvin, antibiotics like penicillin, preparations containing St John's Wort
What are the health risks of Diane 35?
Combination contraceptive pills like Diane 35 can increase risk of thrombosis (blood clots), which can have serious consequence depending on where the clot forms. There is also an increased risk of breast cancer.
How should Diane 35 be taken?
You should take your Diane 35 swallowed whole with a glass of water once daily at the same time each day and follow the instructions provided. Each pack of Diane 35 contains 21 pills and you should take one tablet a day for 21 days and then you will have 7 days off, during which time you should have a menstrual bleed. When you have had the 7 tablet-free days, start a new pack the next day (day 8) even if you have not stopped bleeding. If you have gastrointestinal problems like vomiting or diarrhoea within 3-4 hours of taking a tablet, this is the same as missing a pill and you should take other contraceptive precautions for the next 7 days. You should take Diane 35 continually to ensure effective contraception. If y